I’m a voracious reader of mysteries in my spare time. And some juncture in every story, as the detective finds himself staring at the corpse, they ask the inevitable question “Cui Bono — who benefits?” Oddly enough, this is a question that doesn’t get asked often or early enough in the drug discovery and development […]
Cui Bono? Finding Super Responders In Clinical Trials Read More »
One of the key pieces of the drug discovery puzzle involves determining the clinical relevance of the target. Over the past few years big pharma have been pulling back from this critical part of the drug discovery process and ceding this territory to biotech startups and academia. Until recently, the only major database that could
ClinVar – A database of mutations and their clinical relevance Read More »
During the recent ASCO GI conference, the big news was the release of the results of the Abraxane trials. The data show that the lives of pancreatic cancer patients can be extended by two months when adding Abraxane into the standard gemcitabine treatment regimen. Sally Church at the PharmaStrategy blog gave a good overview of
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News In this weeks news: ABRAXANE Demonstrates Statistically Significant Improvement in Overall Survival for Patients with Advanced Pancreatic Cancer in Phase III Study – Yahoo! Finance MONTPELLIER, France: Skuldtech and AB Science Announce the Identification of New Predictive Markers for Pancreatic Cancer Survival Associated with Masitinib Treatment | Business Wire | Rock Hill Herald Online
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News In this weeks news: “Pancreas In A Dish” Will Show How Pancreatic Cancer Forms A tiny, living 3-D organ model of pancreatic ducts has been created by researchers in Toronto to help them understand pancreatic cancer, which is one of the deadliest yet least understood of all cancers. This new model could lead to
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News In this weeks news: AACR: New Treatments Studied for Pancreatic Cancer –Doctors Lounge Targeting the hedgehog signaling pathway with a smoothened antagonist, GDC-0449, in combination with gemcitabine achieves partial response in some metastatic pancreatic cancer patients; and targeted depletion of the multi-functional cell membrane protein RLIP76 can cause pancreatic cancer tumors in mice to
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This week’s collection of news and journal articles include a number of announcements made at the recent AACR meeting in Chicago. News In this weeks news: Whole genome sequencing not informative for all, Johns Hopkins study shows | e! Science News With sharp declines in the cost of whole genome sequencing, the day of accurately
Pancreatic Cancer News From AACR Read More »
The week American Association of Cancer Research (AACR) kicks off its annual meeting in Chicago, and we’ll be bringing you the latest announcements. News In this weeks news: Health News – Metformin May Improve Pancreatic Cancer Prognosis in Patients With Diabetes Medical Xpress: The protein survivin could be a useful biomarker for pancreatic cancer Clovis
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News In this week’s news includes stories about a viral therapy for pancreatic cancer undergoing preclinical development, the use of a drug to penetrate the stroma surrounding pancreatic cancer tumors at the Fred Hutchinson Institute. You may remember this approach being pioneered by Dan Van Hoff at TGEN. Nuvilex discusses Cell-in-a-Box technology used for pancreatic
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In answer to the perennial question, “why is there no cure for cancer”, Ed Yong from Discover Magazine discusses the complexity of the tumor microenvironment and why this makes finding new therapeutics especially challenging. News In this weeks news: Mouse ‘avatars’ could aid pancreatic cancer therapy : Nature News & Comment Mouse ‘avatars’ could in
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